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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49101badf35ad2468dbc44db34e76190ac3390977ccd1e4f99ab26aa33f32d0a' 
  AND token = 'JR+G1MEzUvM926N8eoCi2SCgK7aMm9W1GRal8RJV2uM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}