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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd78ffd53d5c053d945c0c3794ee5506af7ecb167e72dffa6e50bedb727282b1c' 
  AND token = '/kofbc4/AEhGl4pvNNzT3AHxgiI3SPDDVYyWXg/Cyb0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}