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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fc49bad4c0f34829543f4dce879cf36ff1b2bac5d498fde1be26c313666ed153' 
  AND token = 'NEUvbZ2URPVaUGzylK9Mf5BnGH9d/i7fP/WiMNTddxM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}