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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e65eb44eade387853d9dde8c82e239780d57c610331572f0553c75e198b60716' 
  AND token = 'aX/s66GrsVQdOPYn6h6xZ44WXcxHWO7T3aIB/6psR3c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}