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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43ad48907e33e9432220f12feaf991ccb398f0aaa3e1e0e60860c5ecc4c51ca5' 
  AND token = 'iUJRJ/F00LMDxmSLVXG5meVj4ITnYFpsUSuD5x0AkZE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}