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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '64f6c78fd4a56938a193247e9c7aa421c5f7474458f91e9065c905621890c2cd' 
  AND token = 'O4FPVXwx4KeLLTNeZUZG14twWwHsO5Ja6oW5b0SN5iw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}