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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9271725ddce29930897c26afa0f8992b802f28b98ed7f15dbf4b818df80bbcd3' 
  AND token = 'xf/xr7YjdmwIjCDFS2b2XR1prA+y9wyqhWfkGJgSDyU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}