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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '538808d50129c6f76e3160e44191e89026a780d01e807ea2fb46681c7d9b8bbe' 
  AND token = '294AaCDXBz/RPpV+tIiTSFVgwDy1Ei0k+CT5VmU8Jco=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}