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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cc552f25e2c935307352acd949472f842223672a280bc68cf8abf918b62a2ad1' 
  AND token = 'pGMr0mi3/mR7qaVPI9CvU+tRceU1TW3CK6ZGuQcGUwA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}