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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b78bf348435e097effa53a5f67b8da6f0f60105b3690683a427a409c8750547' 
  AND token = 'ZID+dnZJryPaNXpZFjh2nLAY57lxasg6V3ucXS8U1Bg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}