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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '57e12dd52eb59044d966e09b5269eaf92f626c4848745ad8ac34d9b6b85b0f80' 
  AND token = 'mELc/iBtj1VYGO2CnUhyy14SMijlVYMSlwZs/hSiN+c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}