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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2287450605ac42bccdcee74fcb776db59a06609c66e8a7b4a835c59c67922d55' 
  AND token = 'XdUuBUd2sEth3drYSKkz1PKOEi6l/FgzEra3nVzdmp8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}