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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49a5e4c656e62af35544036c9965ebf4ff8d5e429e237a672a0df04996070a55' 
  AND token = 'zBK1Uh90s8EUE6EnMZ86VatE4S6vkPcyIz5GeSI47dA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}