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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e2ab0e05f6ca14d79b90f58b9bbfd2079d737754818aa1be377ff942223ddcd4' 
  AND token = 'T3w9Uh/JQl/4ogotMOR4qjSwcC41qwnZ0lrFVb27hlI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00043

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}