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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2578ca8fa4b03eecbd901567686a9a926ef3c2b5ea53a3f4056468098931001b' 
  AND token = '1D3gkrvNOt0FIiDODeBSKhqYpsVjVZyIpcyeHRc9R5Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}