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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c15b21395a1669f4834fbedeac2a2acc42612beb1dd380281a0f0671ad3214da' 
  AND token = '/PxdSyy8EmHa45/LOQ3uvVfHytTiinUUNfvGTHPyqgU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}