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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2048b8ba9ebbb3e99cb630da0b8d0d00a7f633eb1c27c10b166349c7d566b934' 
  AND token = 'P0e903ndNgkBTN1WF/CRtPzW5GIIAN3bJr7XdFL2h4I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}