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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd53b5018255059553d7e129eb8b20cccfbc0c589e862da9aaddf39a79d9dff8f' 
  AND token = '1gzhc6C2SlivCY0VU0E+fXwQgGrGsZ2N7pyWu7FmYMw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}