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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e35d8375d5cf29b045ca98f3c11f49279b45f45d13be1553cca5d5f51de3e2a' 
  AND token = 'lIla8sSWDcL6pIxOZtCd5OFjWSs8v7wIoPaUWKMz5c0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}