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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de4df01b28a72989d8513ac6549cdfa6bedeec3e1a0a4b5b68be6e7a8336344b' 
  AND token = 'O7wdIXmdvaWBZgSw+ESqoMMvk/F9DxnUN0KZhUkWsag=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}