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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '648d7908aa92dd2c0b2ade09b1a28765d077b477dca49c7cc011f20174bb5bb8' 
  AND token = 'rF0HB5HjgWDJnf4fOS7G1YFO7xhUXy+5+pag0Iodmvw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00054

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}