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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '166e9e1c2b222a33cc39e635930a4492b8ca42d21c343a0f4bc662d441eed767' 
  AND token = 'ix/ZG3uAY3IL8vzqmWlZ5T0q01oAFR/3eMtWahphqRI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}