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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10a0228210de7a2e70754d66f230722294b554e42e9b3baea7b48e812b784077' 
  AND token = 'SpjksD9tPHbjj+TPuRygW7eqrxW9HRafYGegRoimWd0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}