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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18152f99b6cbecc7ff431ce0ce8832f9fbccd7ed0c0561b145f74f21fbdff085' 
  AND token = 'E9cL7cifbSql0H6/AhnsTi+PQPLoXqmyZIQUrYj3Zwc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}