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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '790ec487bfe1935ae3f017eeaeaf8939bedf0dcbb40530e8293e0870ae5c982b' 
  AND token = 'nS+Go6xByHyIE6OA8xvZtVwYDwCMDSEUNxR52AhLyx0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}