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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6748bfe37ea3f91ea791d7630ecf6bc07fa175d9d4c85edcc51de5a51f522110' 
  AND token = 'H+CHElNpCw8DGdl0oX32jpM333TvmhxonTwbIIjfQ2U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}