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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6224b7e93f72a905c27da721adbbe2d6811738c6dce8063a8371701b08af6eb2' 
  AND token = 'EHFt7IIKZSodRo/RClMG/vcxw4SCk2fX5gQq3xCu6ls=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}