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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f78ba0eb07244ad107d926d4c14cb2f6101f829a49bf148e9ca032be73d6a375' 
  AND token = 'SrYE2Uzxmaim8KA5KrUxsqarg+jQe5fBUbR3WRUGrUo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00057

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}