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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '75f27301406c18057a8fc227755f642eba968c85d580688cbfe3aca83a29c7f4' 
  AND token = 'jX+NOs+laHs65Bt442n4FZaDAh/wUn6GLSy6OAncDxk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}