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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5543a330ddcbc35228ca8e4d8dfa6a231722871c0c9e2f8c40edc5149bbae048' 
  AND token = 'NB5TMIQCgm5qM3qUCx0KKdQBZG5q6EDAHTmYf556GZM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}