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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a44e0b21d53217eb07f66a5612c824042b34d11b31212f48b4f766af8282e4eb' 
  AND token = '6mS2dt1Znz4TeL45jX6I6mEnHXi3hlvSEWENwp7W6cY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}