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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7c6e7d761d4209f40682757a29c91320ba993cbe02327e3094a8b6bd2539d4c1' 
  AND token = 'RXniQrcQMTGaIO6IMVlwN1EO3Qq5iNrTbabVLBFhH3E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}