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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22a0cc77f9bca13436ceffcf91334c21fc8b5fd15f5b2cd1bf7a48e1edfbc8bc' 
  AND token = 'd18Bv6Bx7guPaINa0+FsiDXgIKJYX7XtTsFY18TSoIo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}