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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b51f3e372a29d91c9a8f18695d1feb88d7057aa21037fdd04c92991a0017e202' 
  AND token = 'XUuss/PejVnlETM1g+WckuI1oJtm5WOKsriR+3uh/z0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}