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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '375b350ac186130ce3ef8973df3eee3128ed6de55b934c93ab643b36ac833520' 
  AND token = 'HKfoii0NqTRjBl5+JwCju1KnxksaLufCnftzJYOk7t0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}