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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16de51111cc12d3378dc90c2e57cd61fbf5746a2074ab9d1fa4911c49d9fb114' 
  AND token = '7/A1eqorB/1cUFFoQxzmXyt26/5TYu//XUosh2pTSvc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}