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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '301ca9e68ec3f4b7e81b0183b245b6c66ebc5d0563278a1e1feb922942848226' 
  AND token = 'NF9156v/cy1CP/gnEe8U+Tf5Z3QYSP5g9oKLa8UAPFw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00038

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}