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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd7fa544cf2025a0aa7b0a4aec11353741be25c4339799e4ace9aba7f44b0f30d' 
  AND token = '1+wurEWzV7Pp3OD7I5y1MzTkY9yDWTHUh6ya7WoIb6g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}