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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3bd1f56501cf9149bcc3bb78e4d84b2d0875100adcf01ce548b6e7b6e7678e55' 
  AND token = 'RqsuZBp+z/tiXdSd89X3D+eKk4MTlnfgtXPVEZkG1fY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}