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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed25770cf56b787aab1ce1c15320d61ae5ee19aa03d14aeb87a0d5f1a30fdf0f' 
  AND token = 'JF1Vo8cnAzlBk3sm3EN6YeHQ5CWgQtruvZGcmAVEDTs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}