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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '23eff21a2e6ed89bf2f6228950587bee57afa88ac62bdb6bfae8122655ee0f49' 
  AND token = 'OWhG6gHGAPwrRuSDvyla+JJxDgfjsl1VKZ9FbB1yRSo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}