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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65b990e92961f97a7cee45ddd13e1ca4babe0fca00cd889e9781412d4e3f3e5e' 
  AND token = 'VBVF0B2aZmiqE7/gN2RkX1d+X15YhgGNnCXEn0XEbrc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}