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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '253539706e0dd1a15678b2a5aa10b2caa66cd2323d22d71a984c7235b3205c01' 
  AND token = 'BhrlmpCoKHoh/BgYtHx3zCBAfDpODYhC4nThEbP1LWw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}