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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0a08bcce5b35a1d6c0ddff88f3062d7e327d21ad78b2c7bb29f58bdbef303e0b' 
  AND token = 'ISnVxiyerWEzRHAShRHWz2r6fmPJ6IADPQ3cEmmYD9A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}