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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f87600f9dbec27dad282a2f8cb863ea884f6c1646d1d12b3a15cda7ee9279abd' 
  AND token = 'IeImW0xdOM5LqOz+AeWWbRKKCFfy6UPxcYdMqZ8tfOo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}