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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '393bd812ca913c34e211e1c321c5f85338cf6b59e537f13f9e6a0b798e8a450b' 
  AND token = 'ohbgCItftdJt2aEaRRaU2zfIBsFK4aE4DUwOR3GIFvY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}