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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1b49bd9e40d63d5667feef218d9bf795d9bec1eff89e8f7f2979ae7b41bf4c11' 
  AND token = 'DI/d78ipc8ygtN2pUppTTywPWSHZzxTlhybHnV8OCb0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}