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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d1a0f6cc3f20d132b7935bf9c2a368db7ef9ffde9bd2f148e0bf7c04649a342' 
  AND token = 'tlavLyVczPky0Qe74jrxTluj3TLbMQR72FpTijeBCEQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}