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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50774a7d7441d5106c59a6d25b1fd53c29ace5d934557be661c52726050a2389' 
  AND token = 'gYMaUEu7e0Oz/0RCaSmgBCbED+8yq65tZk937du8nF0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}