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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c246e7e7d2d3bf4bc2d6f034cde3427c66da1164dcd371d9d41b598e3cab17a' 
  AND token = 'R6RvRZF6kwhk6gIbAIOS6BBpHOshVAfad6IMDvpTGXQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}